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As a result of rapid hydrolysis, plasma concentrations of aspirin are always low and rarely exceed 20 ug/ml (111 uM) at ordinary therapeutic doses of 325 to 650 mg (Dovizio et al, 2013) Salicylate can also inhibit COX-1 and COX-2 with little selectivity if high enough plasma concentrations are achieved (Table 1)(Dovivzio et al, 2013): Salicylate IC50 for COX-1 = 1100 uM Salicylate IC50 for COX-2 = 1400 uM Salicylates are excreted mainly by the kidney
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